General advice on COVID-19 for women with LAM

17th March 2020

There are very few reports worldwide, including in China, of women with LAM becoming infected with COVID-19 and so the following points are based on UK government advice and our best judgement.


Disease risk for women with LAM

  • People with underlying respiratory problems are at higher risk of complications from COVID-19 than people without lung disease. In line with this it is likely that women with LAM are also at greater risk of more serious complications from COVID-19 infection than people without lung disease or other serious health problems. 
  • Treatment with rapamycin (Sirolimus) may increase the risk of more severe disease although the evidence on this is mixed.
  • Other medical problems in addition to LAM and increasing age may also increase the risk of more severe COVID-19 infection


Possible risk of more severe COVID-19 infection in women with LAM

Disease Category: FEV1 more than 70% predicted and not on rapamycin

Risk of COVID-19 complications: Normal

Recommendation: Same as general population recommendations.


Disease Category: FEV1 between 50 and 70% whether on rapamycin or not or FEV1 more than 70% predicted and taking rapamycin

Risk of COVID-19 complications: Increased

Recommendation: Follow recommendations for elderly and people with underlying conditions.*


Disease Category: FEV1 less than 50% or anyone requiring supplemental oxygen regardless of lung function or people post-lung transplant

Risk of COVID-19 complications: High

Recommendation: Follow recommendations for elderly and people with underlying conditions.*


Hygiene measures to stop the virus spreading

  • Wash your hands thoroughly with hot water and soap for approximately 30 seconds and ensure you dry them properly. If you are outdoors use an alcohol-based hand sanitiser gel that has a minimum 60% alcohol content 
  • Do not touch your eyes, nose or mouth if your hands are not clean
  • Cover your mouth and nose with a tissue when you cough or sneeze and encourage other people around you to do the same
  • Cough into your elbow or the crook of your arm to reduce the spread of germs and all used tissues should be binned as soon as possible


Avoiding sources of infection

  • As the virus becomes more prevalent the risk of contracting it becomes more likely. All people are now being discouraged to avoid any unnecessary gathering, including public places and social gatherings.
  • *Although Public Health England are not recommending people self-isolate now, the guidance is changing rapidly and people with LAM, particularly with increased and high risk of severe COVID-19 complications highlighted above, may want to avoid or at least minimise contact with people outside their close family, particularly avoiding crowded areas and public transport. 
  • Work from home, if you can.
  • If there are specific issues at your place of work or child’s school, it is appropriate to take advice from your occupational health team or GP.
  • If a member of your household is self-isolating due to symptoms, it is important to maintain hygiene measures at home also.


Sources of up to date information

This is a rapidly evolving situation, so please ensure you regularly check the NHS advice page here for the latest advice.

The British Lung Foundation also have a very useful page here with some advice for people with lung conditions.



This content was created for general informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. These recommendations are based solely on expert opinion, and the advice of your personal physician takes precedence over them. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Do no disregard professional medical advice or delay in seeking it because of something you have read here.